Viral-induced inflammation is accompanied by beta-amyloid plaque reduction in brains of amyloid precursor protein transgenic Tg2576 mice.

@article{Stahl2006ViralinducedII,
  title={Viral-induced inflammation is accompanied by beta-amyloid plaque reduction in brains of amyloid precursor protein transgenic Tg2576 mice.},
  author={Tobias Stahl and Christine Reimers and R Johne and Reinhard Schliebs and Johannes Seeger},
  journal={The European journal of neuroscience},
  year={2006},
  volume={24 7},
  pages={1923-34}
}
Amyloid plaques, one of the neuropathological hallmarks of Alzheimer's disease, and their main constituent, the amyloid beta-peptide (Abeta), are triggers of the activation of innate inflammatory mechanisms involving the activation of microglia. To dissect the effects of a non-Abeta-specific microglial activation on the Abeta metabolism, we employed a viral infection-based model. Transgenic mice expressing a mutated form of the human amyloid precursor protein (Tg2576) were used. In preceding… CONTINUE READING
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