Viral hijacking of G-protein-coupled-receptor signalling networks

  title={Viral hijacking of G-protein-coupled-receptor signalling networks},
  author={Akrit Sodhi and Silvia Montaner and J. Silvio Gutkind},
  journal={Nature Reviews Molecular Cell Biology},
Viruses use a surprising diversity of approaches to hijack G-protein-coupled receptors and harness their activated intracellular signalling pathways. All of these approaches ultimately function to ensure viral replicative success and often contribute to their pathogenesis. Indeed, a single virus might deploy a repertoire of these strategies to regulate key intracellular survival, proliferative and chemotactic pathways. Understanding the contribution of these biochemical routes to viral… CONTINUE READING