Viral haemorrhagic disease of rabbits in Mexico: epidemiology and viral characterization.

  title={Viral haemorrhagic disease of rabbits in Mexico: epidemiology and viral characterization.},
  author={Douglas A. Gregg and Christie House and Roberto J Meyer and Mary Lou Berninger},
  journal={Revue scientifique et technique},
  volume={10 2},
A fatal disease of rabbits was first reported in the People's Republic of China in 1984. [] Key Result In pathogenesis studies, the primary sites of replication were in the small intestinal crypt and villous epithelium, hepatocytes and splenic lymphocytes. Many organs, including the lung and kidney, contained acutely infarcted tissue and haemorrhages resulting from a terminal disseminated intravascular coagulopathy. The disease and the characteristics of the virus isolated in Mexico are similar to isolates…

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  • 1997
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Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures.
  • S. Hsu, L. Raine, H. Fanger
  • Biology, Chemistry
    The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
  • 1981
The ABC method, which involves an application of biotin-labeled secondary antibody followed by the addition of avidin-biotin-peroxidase complex, gives a superior result when compared to the unlabeled antibody method.
  • I. W. Mclean, P. Nakane
  • Biology
    The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
  • 1974
Using this fixative and the peroxidase-labeled antibody technique, basement membrane antigen was localized within the cisternae of endoplasmic reticulum of parietal yolk sac cells and in extracellular basement membranes with adequate tissue preservation, a task which has not been successfully accomplished by conventional fixatives.
Status report: outbreak of viral haemorrhagic disease in rabbits in Mexico
  • In Symposium
  • 1989
- Necrotic hepatitis of rabbits : a parvovirus
  • Foreign Anim . Dis . Rep .
  • 1989
A new viral disease in rabbits
  • (in Chinese). Anim. Hus. vet. Med.,
  • 1984
-L'epatite necrotica infettiva del coniglio. Profilo patogenetico di una nuova malattia emorragica. Riv. Coniglicoltura
  • -L'epatite necrotica infettiva del coniglio. Profilo patogenetico di una nuova malattia emorragica. Riv. Coniglicoltura
  • 1988
Report on 100 cases of rabbit plague (in Chinese)
  • Infect. Dis. dom. Anim.,
  • 1986
Aetiological studies on an acute fatal disease of Angora rabbits: so-called rabbit viral sudden death
  • Korean J. vet. Res
  • 1987
-Pathological studies on a viral septicaemia in rabbits (in Chinese)
  • Shanghai J. Anim. Hus. vet. Med
  • 1985