Viral escape from antisense RNA.

@article{Bull1998ViralEF,
  title={Viral escape from antisense RNA.},
  author={James J Bull and Allan Jacobson and Marty R Badgett and Ian J Molineux},
  journal={Molecular microbiology},
  year={1998},
  volume={28 4},
  pages={
          835-46
        }
}
RNA coliphage SP was propagated for several generations on a host expressing an inhibitory antisense RNA complementary to bases 31-270 of the positive-stranded genome. Phages evolved that escaped inhibition. Typically, these escape mutants contained 3-4 base substitutions, but different sequences were observed among different isolates. The mutations were located within three different types of structural features within the predicted secondary structure of SP genomic RNA: (i) hairpin loops; (ii… CONTINUE READING

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