Viral dynamics of early HIV infection in neonatal macaques after oral exposure to HIV-2287: an animal model with implications for maternal-neonatal HIV transmission.

@article{Herz2002ViralDO,
  title={Viral dynamics of early HIV infection in neonatal macaques after oral exposure to HIV-2287: an animal model with implications for maternal-neonatal HIV transmission.},
  author={Arnd M. Herz and Michael N. Robertson and Jonathan B Lynch and Ann Marie Schmidt and Mark Barry Rabin and Cedar Sherbert and Michael B. Agy and D. Nelson Anderson and Shiu Lok Hu and Phillip Greenberg and William Markha Morton},
  journal={Journal of medical primatology},
  year={2002},
  volume={31 1},
  pages={
          29-39
        }
}
A model of vertical HIV transmission was developed using oral HIV-2(287) exposure of newborn Macaca nemestrina. The minimal Animal Infectious Dose for this oral route was found to be 10-fold higher than that for atraumatic viral transmission across other mucosal membranes (vaginal/rectal) of juvenile macaques. However, once infection was established, viral replication was rapid and plasma viremia could be detected by reverse-transcriptase polymerase chain reaction and viral co-culture within 1… CONTINUE READING

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