Viral dynamics during primary simian immunodeficiency virus infection: effect of time-dependent virus infectivity.

@article{Vaidya2010ViralDD,
  title={Viral dynamics during primary simian immunodeficiency virus infection: effect of time-dependent virus infectivity.},
  author={Naveen K. Vaidya and Ruy M. Ribeiro and Christopher J Miller and Alan S. Perelson},
  journal={Journal of virology},
  year={2010},
  volume={84 9},
  pages={4302-10}
}
A recent experiment involving simian immunodeficiency virus (SIV) infection of macaques revealed that the infectivity of this virus decreased over the first few months of infection. Based on this observation, we introduce a viral dynamic model in which viral infectivity varies over time. The model is fit to viral load data from eight (donor) monkeys infected by intravaginal inoculation of SIVmac251, three monkeys infected by intravenous inoculation of virus isolated from the donors during the… CONTINUE READING

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