Viral dsRNA inhibitors prevent self-association and autophosphorylation of PKR.

@article{McKenna2007ViralDI,
  title={Viral dsRNA inhibitors prevent self-association and autophosphorylation of PKR.},
  author={Sean A McKenna and Darrin A Lindhout and Takashi Shimoike and Colin Echeverr{\'i}a Aitken and Joseph D. Puglisi},
  journal={Journal of molecular biology},
  year={2007},
  volume={372 1},
  pages={103-13}
}
Host response to viral RNA genomes and replication products represents an effective strategy to combat viral invasion. PKR is a Ser/Thr protein kinase that binds to double-stranded (ds)RNA, autophosphorylates its kinase domain, and subsequently phosphorylates eukaryotic initiation factor 2alpha (eIF2alpha). This results in attenuation of protein translation, preventing synthesis of necessary viral proteins. In certain DNA viruses, PKR function can be evaded by transcription of highly structured… CONTINUE READING

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