Viral determinants of age-dependent virulence of Sindbis virus for mice.

  title={Viral determinants of age-dependent virulence of Sindbis virus for mice.},
  author={Pamela C Tucker and Ellen G. Strauss and Richard J. Kuhn and James H. Strauss and Diane E Griffin},
  journal={Journal of virology},
  volume={67 8},
Many alphaviruses cause more severe disease in young animals than in older animals. The age-dependent resistance to severe disease is determined primarily by maturation of the host, but strains of virus can be selected that overcome the increased resistance of mature animals. Sindbis virus (SV) strain AR339 causes fatal encephalitis in newborn mice and nonfatal encephalitis in weanling mice, whereas NSV, a neuroadapted strain of SV, causes fatal encephalitis in weanling as well as newborn mice… CONTINUE READING


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