Viral cytopathogenicity correlated with integration of ubiquitin-coding sequences.

@article{Meyers1991ViralCC,
  title={Viral cytopathogenicity correlated with integration of ubiquitin-coding sequences.},
  author={Gregor Meyers and Norbert Tautz and Edward J Dubovi and H. Jurgen Thiel},
  journal={Virology},
  year={1991},
  volume={180 2},
  pages={
          602-16
        }
}
The RNA genomes of cytopathogenic bovine viral diarrhea virus (BVDV) isolates contain insertions highly homologous to cellular sequences. For two of them the insert was identified as ubiquitin coding sequence. The genome of BVDV Osloss contains exactly one ubiquitin gene monomer. In the case of BVDV CP1 the cellular insertion comprises one complete ubiquitin gene and part of a second monomer. The host cell-derived element in the CP1 genome is embedded in a large duplication of about 2.4 kb of… CONTINUE READING
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