Viral cysteine proteases are homologous to the trypsin-like family of serine proteases: structural and functional implications.

  title={Viral cysteine proteases are homologous to the trypsin-like family of serine proteases: structural and functional implications.},
  author={J. Bazan and R. Fletterick},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={85 21},
  • J. Bazan, R. Fletterick
  • Published 1988
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
Proteases that are encoded by animal picornaviruses and plant como- and potyviruses form a related group of cysteine-active-center enzymes that are essential for virus maturation. We show that these proteins are homologous to the family of trypsin-like serine proteases. In our model, the active-site nucleophile of the trypsin catalytic triad, Ser-195, is changed to a Cys residue in these viral proteases. The other two residues of the triad, His-57 and Asp-102, are otherwise absolutely conserved… Expand
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Nature ( London ) 329 , 351 - 354
  • 1987