Viral carcinogenesis in skin cancer.

@article{MolhoPessach2007ViralCI,
  title={Viral carcinogenesis in skin cancer.},
  author={Vered Molho-Pessach and Michal Lotem},
  journal={Current problems in dermatology},
  year={2007},
  volume={35},
  pages={
          39-51
        }
}
The skin is an organ in which direct contact with viruses, solar UV irradiation and increased susceptibility to immune suppression gather to support viral tumorigenesis. Viruses transform keratinocytes by activation of cancer-promoting genes. Viral proteins may directly act as oncogenes that drive cells to proliferate or generate inflammatory responses and cause regeneration of injured cells that eventually lead to malignant transformation. Accelerated viral carcinogenesis is observed in the… Expand
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References

SHOWING 1-10 OF 83 REFERENCES
Chapter 8: Human papillomavirus and skin cancer.
  • H. Pfister
  • Medicine
  • Journal of the National Cancer Institute. Monographs
  • 2003
TLDR
The question with regard to high-risk HPV types should be readdressed in case-control studies on the basis of serology, which can reveal viral activities over years, and the kinetics of HPV activation relative to tumor development should be determined. Expand
Impact of transforming viruses on cellular mutagenesis, genome stability, and cellular transformation
TLDR
Mechanisms utilized by these viral oncoproteins, Tax, HBx, and E6/E7, to mediate genomic instability and cellular transformation are discussed. Expand
Repair of UV-induced thymine dimers is compromised in cells expressing the E6 protein from human papillomaviruses types 5 and 18
TLDR
Results show that unrepaired DNA damage can be observed in UV-B-irradiated cells expressing the E6 protein of HPV types found in cervical and epithelial cancers, and such cells have the ability to overcome the G1 cell cycle checkpoint induced as a result of un repaired DNA. Expand
HPV‐associated skin disease
TLDR
Recent molecular studies reveal a likely role for HPV infection in skin carcinogenesis as a co‐factor in association with UV, which is well established that solar ultraviolet (UV) irradiation is the major risk factor for developing NMSC. Expand
Advances in antiviral therapy.
Infections with five of the herpesviruses (herpes simplex virus 1 [HSV-1], HSV-2, varicella zoster virus, Epstein-Barr virus, and cytomegalovirus) are treated with topical or systemic antiviralExpand
Human papillomavirus immortalization and transformation functions.
TLDR
The state of the field at the time of the 19th International Papillomavirus Workshop in September 2001 with respect to the HPV encoded oncoproteins is reviewed. Expand
The Kaposi's Sarcoma-Associated Herpesvirus G Protein-Coupled Receptor Has Broad Signaling Effects in Primary Effusion Lymphoma Cells
TLDR
KSHV/human herpesvirus 8 [HHV-8], a gamma-2-herpesvirus responsible for Kaposi's sarcoma as well as primary effusion lymphoma, is a lymphotropic virus that has pirated many mammalian genes involved in inflammation, cell cycle control, and angiogenesis and vGPCR is a homologue of the human interleukin-8 receptor. Expand
NF-kappaB functions as a tumour promoter in inflammation-associated cancer.
TLDR
It is shown that the inflammatory process triggers hepatocyte NF-kappaB through upregulation of tumour-necrosis factor-alpha (TNFalpha) in adjacent endothelial and inflammatory cells, and is therefore a potential target for cancer prevention in chronic inflammatory diseases. Expand
Selective mechanisms utilized by persistent and oncogenic viruses to interfere with antigen processing and presentation
  • R. Ehrlich
  • Biology, Medicine
  • Immunologic research
  • 1995
TLDR
This review describes selective mechanisms utilized by viruses for interference with antigen processing and presentation, and addresses their significance for in vivo viral persistence and tumor progression. Expand
Mucosal human papillomavirus types in squamous cell carcinomas of the uterine cervix and subsequently on fingers
TLDR
The hypothesis of a possible transmission of patients’ genital HPV infections to fingers is supported and a newly developed ‘neighbour primer’ polymerase chain reaction (PCR) for HPV 16 DNA was shown to be superior to conventional general and type‐specific HPV PCR tests. Expand
...
1
2
3
4
5
...