Viral blip dynamics during highly active antiretroviral therapy.

  title={Viral blip dynamics during highly active antiretroviral therapy.},
  author={Michele Di Mascio and Martin Markowitz and Michael Louie and Christine Hogan and Arlene M Hurley and Chris Chung and David D. Ho and Alan S. Perelson},
  journal={Journal of virology},
  volume={77 22},
Although intermittent episodes of low-level viremia are often observed in well-suppressed highly active antiretroviral therapy (HAART)-treated patients, the timing and amplitude of viral blips have never been examined in detail. We analyze here the dynamics of viral blips, i.e., plasma VL measurements of >50 copies/ml, in 123 HAART-treated patients monitored for a mean of 2.6 years (range, 5 months to 5.3 years). The mean (+/- the standard deviation) blip frequency was 0.09 +/- 0.11/sample… CONTINUE READING


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