Viral antigen density and confinement time regulate the reactivity pattern of CD4 T-cell responses to vaccinia virus infection.

@article{Vanguri2013ViralAD,
  title={Viral antigen density and confinement time regulate the reactivity pattern of CD4 T-cell responses to vaccinia virus infection.},
  author={Vijay K. Vanguri and Christopher C. Govern and Rebecca Smith and Eric S. Huseby},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2013},
  volume={110 1},
  pages={288-93}
}
T-cell recognition of ligands is polyspecific. This translates into antiviral T-cell responses having a range of potency and specificity for viral ligands. How these ligand recognition patterns are established is not fully understood. Here, we show that an activation threshold regulates whether robust CD4 T-cell activation occurs following viral infection. The activation threshold was variable because of its dependence on the density of the viral peptide (p)MHC displayed on infected cells… CONTINUE READING

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