• DOI:10.1073/PNAS.0601523103
Corpus ID: 31156993

Viral and therapeutic control of IFN-beta promoter stimulator 1 during hepatitis C virus infection.

@article{Loo2006ViralAT,
  title={Viral and therapeutic control of IFN-beta promoter stimulator 1 during hepatitis C virus infection.},
  author={Y. Loo and D. Owen and K. Li and A. Erickson and C. L. Johnson and P. M. Fish and D. S. Carney and Ting Wang and H. Ishida and M. Yoneyama and T. Fujita and T. Saito and W. Lee and C. Hagedorn and D. Lau and S. Weinman and S. Lemon and M. Gale},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2006},
  volume={103 15},
  pages={
          6001-6
        }
}

• Y. Loo, D. Owen, +15 authors M. Gale
• Published 2006
• Biology, Medicine
• Proceedings of the National Academy of Sciences of the United States of America

Viral signaling through retinoic acid-inducible gene-I (RIG-I) and its adaptor protein, IFN promoter-stimulator 1 (IPS-1), activates IFN regulatory factor-3 (IRF-3) and the host IFN-alpha/beta response that limits virus infection. The hepatitis C virus (HCV) NS3/4A protease cleaves IPS-1 to block RIG-I signaling, but how this regulation controls the host response to HCV is not known. Moreover, endogenous IPS-1 cleavage has not been demonstrated in the context of HCV infection in vitro or in… Expand

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