Viral and host control of cytomegalovirus maturation.

  title={Viral and host control of cytomegalovirus maturation.},
  author={Ritesh Tandon and Edward S. Mocarski},
  journal={Trends in microbiology},
  volume={20 8},
Maturation in herpesviruses initiates in the nucleus of the infected cell, with encapsidation of viral DNA to form nucleocapsids, and concludes with envelopment in the cytoplasm to form infectious virions that egress the cell. The entire process of virus maturation is orchestrated by protein-protein interactions and enzymatic activities of viral and host origin. Viral tegument proteins play important roles in maintaining the structural stability of capsids and directing the acquisition of virus… CONTINUE READING
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