Viral and cellular factors that regulate HIV-1 uncoating.

  title={Viral and cellular factors that regulate HIV-1 uncoating.},
  author={Christopher Aiken},
  journal={Current opinion in HIV and AIDS},
  volume={1 3},
PURPOSE OF REVIEW The immediate events in HIV-1 infection following fusion of HIV-1 particles with the target cells are poorly defined and difficult to study. It is generally thought that the viral capsid undergoes a disassembly process that has broadly been referred to as uncoating. The recent identification of species-specific host restriction factors that target the viral capsid has sparked new interest in retroviral uncoating. RECENT FINDINGS Recent studies have used purified HIV-1 cores… CONTINUE READING

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