Viral RNA-dependent DNA Polymerase: RNA-dependent DNA Polymerase in Virions of Rous Sarcoma Virus

@article{Temin1970ViralRD,
  title={Viral RNA-dependent DNA Polymerase: RNA-dependent DNA Polymerase in Virions of Rous Sarcoma Virus},
  author={Howard M. Temin and Satoshi Mizutani},
  journal={Nature},
  year={1970},
  volume={226},
  pages={1211-1213}
}
Viral RNA-dependent DNA Polymerase: RNA-dependent DNA Polymerase in Virions of Rous Sarcoma Virus 

DNA-directed DNA Polymerase Activity in Oncogenic RNA Viruses

Besides having RNA-dependent DNA polymerase activity, oncogenic RNA viruses possess a DNA-directed DNA polymerase which is distinguished from previously described enzymes of this type in preferring

Viral RNA-dependent DNA Polymerase: RNA-dependent DNA Polymerase in Virions of RNA Tumour Viruses

Two independent groups of investigators have found evidence of an enzyme in virions of RNA tumour viruses which synthesizes DNA from an RNA template, apparently the classical process of information transfer from DNA to RNA can be inverted.

Formation of Viral RNA–DNA Hybrid Molecules by the DNA Polymerase of Sarcoma-Leukaemia Viruses

Viral RNA is the template for the DNA polymerase of the sarcoma-leukaemia viruses: a “natural” RNA-DNA hybrid is formed by annealing viral RNA with the DNA product of theDNA polymerase reaction.

Viral DNA-dependent DNA Polymerase and the Properties of Thymidine Labelled Material in Virions of an Oncogenic RNA Virus

RNA tumour viruses contain a DNA-dependent DNA polymerase which preferentially uses either single or double stranded DNA rich in guanosine and cytosine as template. The virion also contains DNA of

Characterization of the Products of RNA-directed DNA Polymerases in Oncogenic RNA Viruses

Several RNA tumour viruses contain an enzyme that synthesizes a DNA–RNA hybrid using the single stranded viral RNA as template. Hybridization experiments confirm that the DNA strand is complementary

A DNA-dependent DNA Polymerase and a DNA Endonuclease in Virions of Rous Sarcoma Virus

The virion contains a DNA-dependent DNA polymerase which replicates duplex DNA and an endonuclease which attacks it. A ligase system may also be present.

Covalently linked RNA-DNA molecule as initial product of RNA tumour virus DNA polymerase.

Reverse transcriptase from avian myeloblastosis virus initially synthesizes from endogenous RNA template a covalently linked DNA–RNA species, which Verma et al. suggest contains a small RNA primer

RNA Dependent DNA Polymerase Activity in Mammalian Cells

A DNA polymerase that can copy RNA–RNA and RNA–DNA synthetic templates has been found in normal mouse and normal human cells and has properties similar to those of the mouse leukaemia virus enzyme.

Separation of RNA-dependent DNA Polymerase Activity from the Murine Leukaemia Virion

DNA polymerase activity has been separated from intact virions and is found associated with the nucleoid. Antiserum to the viral proteins inhibits this activity.

Synthetic DNA–RNA Hybrids and RNA–RNA Duplexes as Templates for the Polymerases of the Oncogenic RNA Viruses

Six RNA viruses have now been shown to contain DNA polymerase activities directed by single-stranded RNA, double-stranded RNA and double-stranded DNA. It is further demonstrated that DNA–RNA hybrids,
...

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