Viral RNA-dependent DNA Polymerase: RNA-dependent DNA Polymerase in Virions of RNA Tumour Viruses

@article{Baltimore1970ViralRD,
  title={Viral RNA-dependent DNA Polymerase: RNA-dependent DNA Polymerase in Virions of RNA Tumour Viruses},
  author={David Baltimore},
  journal={Nature},
  year={1970},
  volume={226},
  pages={1209-1211}
}
Two independent groups of investigators have found evidence of an enzyme in virions of RNA tumour viruses which synthesizes DNA from an RNA template. This discovery, if upheld, will have important implications not only for carcinogenesis by RNA viruses but also for the general understanding of genetic transcription: apparently the classical process of information transfer from DNA to RNA can be inverted. 
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Besides having RNA-dependent DNA polymerase activity, oncogenic RNA viruses possess a DNA-directed DNA polymerase which is distinguished from previously described enzymes of this type in preferring
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Six RNA viruses have now been shown to contain DNA polymerase activities directed by single-stranded RNA, double-stranded RNA and double-stranded DNA. It is further demonstrated that DNA–RNA hybrids,
Association of the viral reverse transcriptase with an enzyme degrading the RNA moiety of RNA-DNA hybrids.
TLDR
This work has demonstrated that RNA-DNA hybrids have been demonstrated to occur as intermediates in this reaction and single stranded DNA is generated as an early reaction product, which is then replicated to give a double stranded DNA product.
Inhibitors of the RNA and DNA dependent polymerase activities of RNA tumour viruses.
TLDR
RNA viruses of several animal leukaemias and sarcomas possess what seems so far to be a unique enzyme—an RNA dependent DNA polymerase1–6 that might provide drugs for leukaemia and cancer therapy.
RNA-dependent DNA polymerase activity of RNA tumor viruses. V. Rous sarcoma virus single-stranded RNA-DNA covalent hybrids in infected chicken embryo fibroblast cells.
RNA-DNA covalent hybrids containing viral RNA have been isolated from nuclear fractions of Rous sarcoma virus-infected chicken embryo fibroblast cells shortly after virus infection. The formation of
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References

SHOWING 1-10 OF 14 REFERENCES
Viral RNA-dependent DNA Polymerase: RNA-dependent DNA Polymerase in Virions of Rous Sarcoma Virus
TLDR
Viral RNA-dependent DNA Polymerase: RNA- dependent DNA polymerase in Virions of Rous Sarcoma Virus and its role in cell reprograming is studied.
RNA polymerase activity in purified infectious vaccinia virus.
TLDR
It could be predicted that the first viral-induced macromolecular synthesis in cells infected with a double-stranded DNA virus would be the synthesis of RNA and that the RNA polymerase enzyme used to catalyze this synthesis pre-exercise before the initiation of infection.
Reovirus: RNA polymerase activity in purified virions.
On the role of DNA synthesis in avian tumor virus infection.
  • P. Duesberg, P. Vogt
  • Biology, Medicine
    Proceedings of the National Academy of Sciences of the United States of America
  • 1969
Preinfection of chick embryo fibroblasts with an avian tumor virus does not eliminate the requirement of early DNA synthesis for other avian tumor viruses superinfecting the same cells several days
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