Viral Kirsten ras infection differentiates PC12 cells and enhances their survival upon implantation into brain.

Abstract

Neuronal cells from established cell lines can offer a well-characterized source of cells for transplantation to the brain that is an alternative to fetal neurons. The infection of members of the PC12 cell line with a retrovirus containing ras-oncogene leads to their neuronal differentiation without the need of nerve growth factor (NGF). We find that… (More)

Topics

Cite this paper

@article{Okuda1991ViralKR, title={Viral Kirsten ras infection differentiates PC12 cells and enhances their survival upon implantation into brain.}, author={O Okuda and Joseph P. Bressler and Lai Seong Chang and Milton W. Brightman}, journal={Experimental neurology}, year={1991}, volume={113 3}, pages={330-7} }