Viral Factors Induce Hedgehog Pathway Activation in Humans with Viral Hepatitis, Cirrhosis, and Hepatocellular Carcinoma

@inproceedings{Pereira2010ViralFI,
  title={Viral Factors Induce Hedgehog Pathway Activation in Humans with Viral Hepatitis, Cirrhosis, and Hepatocellular Carcinoma},
  author={Thiago de Almeida Pereira and Rafal P. Witek and Wing-Kin Syn and Steve Choi and Shelton S. Bradrick and Gamze F. Karaca and Kolade M. Agboola and Youngmi Jung and Alessia Omenetti and Cynthia A Moylan and Liu Yang and Martin E Fernandez-Zapico and Ravi Jhaveri and Vijay H Shah and Fausto Edmundo Lima Pereira and Anna Mae Diehl},
  booktitle={Laboratory Investigation},
  year={2010}
}
Hedgehog (Hh) pathway activation promotes many processes that occur during fibrogenic liver repair. Whether the Hh pathway modulates the outcomes of virally mediated liver injury has never been examined. Gene-profiling studies of human hepatocellular carcinomas (HCCs) demonstrate Hh pathway activation in HCCs related to chronic infection with hepatitis B virus (HBV) or hepatitis C virus (HCV). Because most HCCs develop in cirrhotic livers, we hypothesized that Hh pathway activation occurs… CONTINUE READING

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