Viral Evolution and Cytotoxic T Cell Restricted Selection in Acute Infant HIV-1 Infection

@inproceedings{GarciaKnight2016ViralEA,
  title={Viral Evolution and Cytotoxic T Cell Restricted Selection in Acute Infant HIV-1 Infection},
  author={Miguel A. Garcia-Knight and Jennifer A. Slyker and Barbara Lohman Payne and Sergei L. Kosakovsky Pond and Thushan I. de Silva and Bhavna H Chohan and Brian Khasimwa and Dorothy A Mbori-Ngacha and Grace John-Stewart and Sarah L Rowland-Jones and Joakim Esbj{\"o}rnsson},
  booktitle={Scientific reports},
  year={2016}
}
Antiretroviral therapy-naive HIV-1 infected infants experience poor viral containment and rapid disease progression compared to adults. Viral factors (e.g. transmitted cytotoxic T- lymphocyte (CTL) escape mutations) or infant factors (e.g. reduced CTL functional capacity) may explain this observation. We assessed CTL functionality by analysing selection in CTL-targeted HIV-1 epitopes following perinatal infection. HIV-1 gag, pol and nef sequences were generated from a historical repository of… CONTINUE READING