Viral Evolution Revealed by Bacteriophage PRD1 and Human Adenovirus Coat Protein Structures

  title={Viral Evolution Revealed by Bacteriophage PRD1 and Human Adenovirus Coat Protein Structures},
  author={Stacy D. Benson and Jaana K. H. Bamford and D. Bamford and R. Burnett},
  • Stacy D. Benson, Jaana K. H. Bamford, +1 author R. Burnett
  • Published 1999
  • Biology, Medicine
  • Cell
  • The unusual bacteriophage PRD1 features a membrane beneath its icosahedral protein coat. The crystal structure of the major coat protein, P3, at 1.85 A resolution reveals a molecule with three interlocking subunits, each with two eight-stranded viral jelly rolls normal to the viral capsid, and putative membrane-interacting regions. Surprisingly, the P3 molecule closely resembles hexon, the equivalent protein in human adenovirus. Both viruses also have similar overall architecture, with… CONTINUE READING

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