Viral Bcl-2 homologs and their role in virus replication and associated diseases.

@article{Polster2004ViralBH,
  title={Viral Bcl-2 homologs and their role in virus replication and associated diseases.},
  author={Brian M Polster and Jonathan Pevsner and Jonathan Hardwick},
  journal={Biochimica et biophysica acta},
  year={2004},
  volume={1644 2-3},
  pages={211-27}
}
Cellular Bcl-2 family proteins regulate a critical step in the mammalian programmed cell death pathway by modulating mitochondrial permeability and function. Bcl-2 family proteins are also encoded by several large DNA viruses, including all known gamma herpesviruses, adenoviruses, and several other unrelated viruses. Viral Bcl-2 proteins can prevent cell death but often escape cellular regulatory mechanisms that govern their cellular counterparts. By evading the "altruistic" suicide of infected… CONTINUE READING

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