Viral Bcl-2 homologs and their role in virus replication and associated diseases.

  title={Viral Bcl-2 homologs and their role in virus replication and associated diseases.},
  author={Brian M Polster and Jonathan Pevsner and Jonathan Hardwick},
  journal={Biochimica et biophysica acta},
  volume={1644 2-3},
Cellular Bcl-2 family proteins regulate a critical step in the mammalian programmed cell death pathway by modulating mitochondrial permeability and function. Bcl-2 family proteins are also encoded by several large DNA viruses, including all known gamma herpesviruses, adenoviruses, and several other unrelated viruses. Viral Bcl-2 proteins can prevent cell death but often escape cellular regulatory mechanisms that govern their cellular counterparts. By evading the "altruistic" suicide of infected… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.
24 Citations
207 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 24 extracted citations


Publications referenced by this paper.
Showing 1-10 of 207 references

Identification of the in vivo role of a viral bcl-2

  • S. Gangappa, L. F. van Dyk, T. J. Jewett, S. H. Speck, H.W.t. Virgin
  • J. Exp. Med
  • 2002
Highly Influential
8 Excerpts

Similar Papers

Loading similar papers…