Viral Appropriation: Laying Claim to Host Nuclear Transport Machinery

  title={Viral Appropriation: Laying Claim to Host Nuclear Transport Machinery},
  author={Tanner M. Tessier and Mackenzie J. Dodge and Martin A. Prusinkiewicz and Joe S. Mymryk},
Protein nuclear transport is an integral process to many cellular pathways and often plays a critical role during viral infection. To overcome the barrier presented by the nuclear membrane and gain access to the nucleus, virally encoded proteins have evolved ways to appropriate components of the nuclear transport machinery. By binding karyopherins, or the nuclear pore complex, viral proteins influence their own transport as well as the transport of key cellular regulatory proteins. This review… 

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    FASEB journal : official publication of the Federation of American Societies for Experimental Biology
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