Viral/Nonviral Chimeric Nanoparticles To Synergistically Suppress Leukemia Proliferation via Simultaneous Gene Transduction and Silencing.

@article{Hong2016ViralNonviralCN,
  title={Viral/Nonviral Chimeric Nanoparticles To Synergistically Suppress Leukemia Proliferation via Simultaneous Gene Transduction and Silencing.},
  author={Cheol Am Hong and Soo Kyung Cho and Julius A. Edson and Jane Kim and Dominique Ingato and Bryan Pham and Anthony Chuang and David A Fruman and Young Jik Kwon},
  journal={ACS nano},
  year={2016},
  volume={10 9},
  pages={
          8705-14
        }
}
Single modal cancer therapy that targets one pathological pathway often turns out to be inefficient. For example, relapse of chronic myelogenous leukemia (CML) after inhibiting BCR-ABL fusion protein using tyrosine kinase inhibitors (TKI) (e.g., Imatinib) is of significant clinical concern. This study developed a dual modal gene therapy that simultaneously tackles two key BCR-ABL-linked pathways using viral/nonviral chimeric nanoparticles (ChNPs). Consisting of an adeno-associated virus (AAV… CONTINUE READING
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