VirB11 ATPases are dynamic hexameric assemblies: new insights into bacterial type IV secretion.

@article{Savvides2003VirB11AA,
  title={VirB11 ATPases are dynamic hexameric assemblies: new insights into bacterial type IV secretion.},
  author={Savvas N. Savvides and H. Yeo and Moriah R Beck and Franca Blaesing and Rudi Lurz and Erich Lanka and Renate Buhrdorf and Wolfgang Fischer and Rainer Haas and Gabriel Waksman},
  journal={The EMBO journal},
  year={2003},
  volume={22 9},
  pages={1969-80}
}
The coupling of ATP binding/hydrolysis to macromolecular secretion systems is crucial to the pathogenicity of Gram-negative bacteria. We reported previously the structure of the ADP-bound form of the hexameric traffic VirB11 ATPase of the Helicobacter pylori type IV secretion system (named HP0525), and proposed that it functions as a gating molecule at the inner membrane, cycling through closed and open forms regulated by ATP binding/hydrolysis. Here, we combine crystal structures with… CONTINUE READING