Viperin (cig5), an IFN-inducible antiviral protein directly induced by human cytomegalovirus

@article{Chin2001ViperinA,
  title={Viperin (cig5), an IFN-inducible antiviral protein directly induced by human cytomegalovirus},
  author={K. C. Chin and P. Cresswell},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2001},
  volume={98},
  pages={15125 - 15130}
}
  • K. C. Chin, P. Cresswell
  • Published 2001
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • Little is known about the mechanism by which IFNs inhibit human cytomegalovirus (HCMV) replication. Indeed, infection of fibroblasts with HCMV initiates the expression of a subset of type I IFN-inducible genes whose role in the infectious process is unclear. We describe here the identification of a cytoplasmic antiviral protein that is induced by IFNs, by HCMV infection, and by the HCMV envelope protein, glycoprotein B (gB). Stable expression of the protein in fibroblasts inhibits productive… CONTINUE READING
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