Viper venom components affecting angiogenesis.

@article{Huang2001ViperVC,
  title={Viper venom components affecting angiogenesis.},
  author={T. F. Huang and C. H. Yeh and W B Wu},
  journal={Haemostasis},
  year={2001},
  volume={31 3-6},
  pages={192-206}
}
Angiogenesis is a complex process consisting of the proliferation, migration and differentiation of endothelial cells, and it is essential for the progression of malignant solid tumors. In this report, we examine the effects of disintegrins (e.g. rhodostomin and accutin) and glycoprotein-lb-binding proteins (e.g. agkistin) on each step in angiogenesis using in vitro and in vivo models. Rhodostomin (but not agkistin) inhibited the viability of human umbilical vein endothelial cells (HUVECs) and… CONTINUE READING
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