Violacein synergistically increases 5-fluorouracil cytotoxicity, induces apoptosis and inhibits Akt-mediated signal transduction in human colorectal cancer cells.

@article{Kodach2006ViolaceinSI,
  title={Violacein synergistically increases 5-fluorouracil cytotoxicity, induces apoptosis and inhibits Akt-mediated signal transduction in human colorectal cancer cells.},
  author={Liudmila L. Kodach and Carina L. Bos and Nelson D’olivares Dur{\'a}n and Maikel Petrus Peppelenbosch and Carmen Ver{\'i}ssima Ferreira and James C.H. Hardwick},
  journal={Carcinogenesis},
  year={2006},
  volume={27 3},
  pages={
          508-16
        }
}
Despite recent additions to the armory of chemotherapeutic agents for colorectal cancer (CRC) treatment, the results of chemotherapy remain unsatisfactory. 5-Fluorouracil (5-FU) still represents the cornerstone of treatment and resistance to its actions is a major obstacle to successful chemotherapy. Therefore, new active agents in CRC and agents that increase the chemosensitivity of cancer cells to 5-FU are still urgently required. Violacein, a pigment isolated from Chromobacterium violaceum… CONTINUE READING

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