Violacein, an indole-derived purple-colored natural pigment produced by Janthinobacterium lividum, inhibits the growth of head and neck carcinoma cell lines both in vitro and in vivo

@article{Masuelli2015ViolaceinAI,
  title={Violacein, an indole-derived purple-colored natural pigment produced by Janthinobacterium lividum, inhibits the growth of head and neck carcinoma cell lines both in vitro and in vivo},
  author={Laura Masuelli and Fabrizio Pantanella and Giuseppe La Regina and Monica Benvenuto and Massimo Fantini and Rosanna Mattera and Enrica Di Stefano and Maurizio Mattei and Romano Silvestri and Serena Schippa and Vittorio Manzari and Andrea Modesti and Roberto Bei},
  journal={Tumor Biology},
  year={2015},
  volume={37},
  pages={3705-3717}
}
Violacein (VIO; 3-[1,2-dihydro-5-(5-hydroxy-1H-indol-3-yl)-2-oxo-3H-pyrrol-3-ylidene]-1,3-dihydro-2H-indol-2-one), an indole-derived purple-colored pigment, produced by a limited number of Gram-negative bacteria species, including Chromobacterium violaceum and Janthinobacterium lividum, has been demonstrated to have anti-cancer activity, as it interferes with survival transduction signaling pathways in different cancer models. Head and neck carcinoma (HNC) represents the sixth most common and… CONTINUE READING

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