Vinyl sulfone building blocks in covalently reversible reactions with thiols †

@inproceedings{Schneider2015VinylSB,
  title={Vinyl sulfone building blocks in covalently reversible reactions with thiols †},
  author={Thomas H. Schneider and Max Rieger and Kay Ansorg and Alexandre N. Sobolev and Tanja Schirmeister and Bernd Engels and Simon Grabowsky},
  year={2015}
}
In the present study we use quantum-chemical calculations to investigate how the reactivity of vinyl sulfone-based compounds can be modified from an irreversible to a reversible reaction with thiols. Based on the predictions from theory, an array of nine different vinyl sulfones with systematically varying substitution pattern was synthesized and their crystal structures were determined. Subsequent Hirshfeld surface analyses employing the principle of electrostatic complementarity aid the… CONTINUE READING