Vinyl ethers of choline and congeners.

  title={Vinyl ethers of choline and congeners.},
  author={Joseph Gerard Cannon and Aleem Gangjee},
  journal={Journal of medicinal chemistry},
  volume={19 7},
The vinyl ethers of choline and of its alpha- and beta-methyl homologues were prepared to determine their cholinergic effects and to determine whether a separation of the dual physiologic activity (nicotinic and muscarinic) reported for the vinyl ether of choline could be achieved by this modification. A literature method of vinyl transetherification of amino alcohols has been studied and modified. The ethyl ethers of choline and of alpha- and beta-methylcholine were prepared for comparison… CONTINUE READING

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