Vinyl chloride: dominant lethal studies in male CD-1 mice.

  title={Vinyl chloride: dominant lethal studies in male CD-1 mice.},
  author={Diana Anderson and M. C. E. Hodge and Iain F H Purchase},
  journal={Mutation research},
  volume={40 4},
The mutagenic activity of vinyl chloride (VC) at three exposure levels was assessed in fertile male CD-1 mice with the dominant lethal test. Male mice were exposured by inhalation to VC at 3000, 10,000 and 30,000 ppm for 6 h a day for 5 days. By comparison with control males exposed to air, no mutagenic effects on any maturation stage of spermatogeneisis in treated males were detected. There was no significant increase in the number of post-implantational early foetal deaths as shown by the… CONTINUE READING