Vinpocetine Selectively Inhibits Neurotransmitter Release Triggered by Sodium Channel Activation

@article{Sitges1999VinpocetineSI,
  title={Vinpocetine Selectively Inhibits Neurotransmitter Release Triggered by Sodium Channel Activation},
  author={Mar{\'i}a Sitges and Vladimir Nekrassov},
  journal={Neurochemical Research},
  year={1999},
  volume={24},
  pages={1585-1591}
}
The effects of vinpocetine on internal Na+ (Nai), cAMP accumulation, internal Ca2+ (Cai) and excitatory amino acid neurotransmitters release, under resting and under depolarized conditions, was investigated in rat striatum synaptosomes. Veratridine (20 μM) or high K+ (30 mM) were used as depolarizing agents. Results show that vinpocetine in the low μM range inhibits the elevation of Nai, the elevation of Cai and the release of glutamate and aspartate induced by veratridine depolarization. In… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 12 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 37 references

Calcium channels coupled to glutamate release.

Progress in brain research • 1998
View 1 Excerpt

Characterization of vinpocetine mechanism of action in rat striatum synaptosomes

M. Sitges, V. Nekrassov
Journal of Neurochemistry • 1998
View 1 Excerpt

Similar Papers

Loading similar papers…