Vinorelbine plus cisplatin vs. observation in resected non-small-cell lung cancer.

  title={Vinorelbine plus cisplatin vs. observation in resected non-small-cell lung cancer.},
  author={Timothy L Winton and Robert R Livingston and David H. Johnson and James R. Rigas and Michael D Johnston and Charles Butts and Yvon Cormier and Glenwood Goss and Richard Inculet and Eric Valli{\`e}res and Willard A Fry and Drew Bethune and Joseph I. G. Ayoub and Keyue Ding and Lesley Seymour and Barbara C Graham and Ming-Sound Tsao and David Gandara and Kenneth A. Kesler and Todd A Demmy and Frances A. Shepherd},
  journal={The New England journal of medicine},
  volume={352 25},
BACKGROUND We undertook to determine whether adjuvant vinorelbine plus cisplatin prolongs overall survival among patients with completely resected early-stage non-small-cell lung cancer. METHODS We randomly assigned patients with completely resected stage IB or stage II non-small-cell lung cancer to vinorelbine plus cisplatin or to observation. The primary end point was overall survival; principal secondary end points were recurrence-free survival and the toxicity and safety of the regimen… CONTINUE READING
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