Vinegar decreases blood pressure by down-regulating AT1R expression via the AMPK/PGC-1α/PPARγ pathway in spontaneously hypertensive rats

@article{Na2015VinegarDB,
  title={Vinegar decreases blood pressure by down-regulating AT1R expression via the AMPK/PGC-1$\alpha$/PPAR$\gamma$ pathway in spontaneously hypertensive rats},
  author={Lixin Na and Xia Chu and Shuo Jiang and Chunjuan Li and Gang Li and Ying He and Yuanxiu Liu and Ying Li and Changhao Sun},
  journal={European Journal of Nutrition},
  year={2015},
  volume={55},
  pages={1245-1253}
}
PurposeVinegar has been reported to lower blood pressure, but its mechanism is unclear. This study explored whether vinegar plays antihypertensive effect by activating AMP-activated protein kinase (AMPK) pathway.MethodsMale spontaneously hypertensive rats (SHRs) were assigned to vinegar, acetic acid, nifedipine, nifedipine + vinegar, or distilled water by oral gavage for 8 weeks. Blood and aortas were analyzed for biochemical indices and protein expression levels. Sv40-transformed aortic rat… Expand

Paper Mentions

Interventional Clinical Trial
This study is to assess the blood pressure lowering effect of rice vinegar when consumed over a 12-week period by healthy adults ages 30-65 years old with prehypertension. Study… Expand
ConditionsPrehypertension
InterventionDietary Supplement
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