Vinculin phosphorylation at residues Y100 and Y1065 is required for cellular force transmission.

@article{Auernheimer2015VinculinPA,
  title={Vinculin phosphorylation at residues Y100 and Y1065 is required for cellular force transmission.},
  author={Vera Auernheimer and Lena A Lautscham and Maria Leidenberger and Oliver Friedrich and Barbara Kappes and Ben Fabry and Wolfgang Heinrich Goldmann},
  journal={Journal of cell science},
  year={2015},
  volume={128 18},
  pages={
          3435-43
        }
}
The focal adhesion protein vinculin connects the actin cytoskeleton, through talin and integrins, with the extracellular matrix. Vinculin consists of a globular head and tail domain, which undergo conformational changes from a closed auto-inhibited conformation in the cytoplasm to an open conformation in focal adhesions. Src-mediated phosphorylation has been suggested to regulate this conformational switch. To explore the role of phosphorylation in vinculin activation, we used knock-out mouse… CONTINUE READING
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Role of vinculin in cellular mechanotransduction.

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References

Publications referenced by this paper.
SHOWING 1-10 OF 66 REFERENCES