Vinculin facilitates cell invasion into three-dimensional collagen matrices.

@article{Mierke2010VinculinFC,
  title={Vinculin facilitates cell invasion into three-dimensional collagen matrices.},
  author={Claudia Tanja Mierke and Philip Kollmannsberger and Daniel P Zitterbart and G. M. Diez and Thorsten M. Koch and Susanna Marg and Wolfgang H. Ziegler and Wolfgang Heinrich Goldmann and Ben Fabry},
  journal={The Journal of biological chemistry},
  year={2010},
  volume={285 17},
  pages={13121-30}
}
The cytoskeletal protein vinculin contributes to the mechanical link of the contractile actomyosin cytoskeleton to the extracellular matrix (ECM) through integrin receptors. In addition, vinculin modulates the dynamics of cell adhesions and is associated with decreased cell motility on two-dimensional ECM substrates. The effect of vinculin on cell invasion through dense three-dimensional ECM gels is unknown. Here, we report how vinculin expression affects cell invasion into three-dimensional… CONTINUE READING

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Vinculin Facilitates Cell Invasion 13130 JOURNAL OF BIOLOGICAL CHEMISTRY VOLUME

J. Guck, S. Schinkinger, +10 authors C. Bilby
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