Vinculin activation is necessary for complete talin binding.

@article{Golji2011VinculinAI,
  title={Vinculin activation is necessary for complete talin binding.},
  author={Javad Golji and Johnny Steven Lam and Mohammad R K Mofrad},
  journal={Biophysical journal},
  year={2011},
  volume={100 2},
  pages={
          332-40
        }
}
Focal adhesions are critical to a number of cellular processes that involve mechanotransduction and mechanical interaction with the cellular environment. The growth and strengthening of these focal adhesions is dependent on the interaction between talin and vinculin. This study investigates said interaction and how vinculin activation influences it. Using molecular dynamics, the interaction between talin's vinculin binding site (VBS) and vinculin's domain 1 (D1) is simulated both before and… CONTINUE READING
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