Vinculin: a novel marker for quiescent and activated hepatic stellate cells in human and rat livers

  title={Vinculin: a novel marker for quiescent and activated hepatic stellate cells in human and rat livers},
  author={S. Kawai and H. Enzan and Y. Hayashi and Yu Jin and Limei Guo and E. Miyazaki and M. Toi and N. Kuroda and M. Hiroi and T. Saibara and H. Nakayama},
  journal={Virchows Archiv},
In liver injuries, the quiescent hepatic stellate cells (HSCs) promptly change to activated HSCs, which are easily identified by the intense immunoreactivity for α-smooth muscle actin. However, reproducible markers for quiescent HSCs in formalin-fixed, paraffin-embedded liver tissue sections have not yet been reported. We immunohistochemically examined the expression of vinculin, one major protein of dense plaques, on cultured LI90 cells and on HSCs in normal and diseased human and rat livers… Expand
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The Normal Liver


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