Vinculin, an intracellular protein localized at specialized sites where microfilament bundles terminate at cell membranes.

@article{Geiger1980VinculinAI,
  title={Vinculin, an intracellular protein localized at specialized sites where microfilament bundles terminate at cell membranes.},
  author={Benjamin Geiger and K. T. Tokuyasu and A H Dutton and S. Jonathan Singer},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1980},
  volume={77 7},
  pages={4127-31}
}
As intracellular protein of 130,000 molecular weight was recently isolated in this laboratory from chicken gizzard smooth muscle. By immunofluorescence observations of cultured chicken fibroblasts, it was shown to be concentrated on the ventral surfaces of the cells where they formed focal adhesions to the substratum [Geiger, B. (1979) Cell 18, 193-205]. Focal adhesions are sites where, inside the fibroblast, microfilament bundles are known to terminate at the cell membrane. The suggestion was… CONTINUE READING

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