Vincristine potentiates the anti-proliferative effect of an aurora kinase inhibitor, VE-465, in myeloid leukemia cells.

@article{Yoshida2011VincristinePT,
  title={Vincristine potentiates the anti-proliferative effect of an aurora kinase inhibitor, VE-465, in myeloid leukemia cells.},
  author={K. Yoshida and T. Nagai and K. Ohmine and Mitsuyo Uesawa and Piyanuch Sripayap and Y. Ishida and K. Ozawa},
  journal={Biochemical pharmacology},
  year={2011},
  volume={82 12},
  pages={
          1884-90
        }
}
Aurora kinases play an essential role in the regulation of mitosis. The kinases are overexpressed in a variety of cancer cells and are involved in tumorgenesis. Although aurora kinase inhibitors are potential agents for treatment of leukemia, the establishment of efficacious combination therapies is an attractive approach for making good use of these agents. In this study, we examined the effects of a specific aurora kinase inhibitor, VE-465, in combination with various conventional anti… Expand
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