Vincristine-induced peripheral neuropathy in pediatric cancer patients.

  title={Vincristine-induced peripheral neuropathy in pediatric cancer patients.},
  author={Erika Mora and Ellen M. Lavoie Smith and Clare Donohoe and Daniel L Hertz},
  journal={American journal of cancer research},
  volume={6 11},
Vincristine is a chemotherapeutic agent that is a component of many combination regimens for a variety of malignancies, including several common pediatric tumors. Vincristine treatment is limited by a progressive sensorimotor peripheral neuropathy. Vincristine-induced peripheral neuropathy (VIPN) is particularly challenging to detect and monitor in pediatric patients, in whom the side effect can diminish long term quality of life. This review summarizes the current state of knowledge regarding… CONTINUE READING


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Randomized double-blind trial of combined modality treatment with or without amifostine in unresectable Vincristine-induced peripheral neuropathy

  • SS Leong, EH Tan, +10 authors PT. Ang
  • Am J Cancer Res
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