Vincristine-induced allodynia in the rat.

  title={Vincristine-induced allodynia in the rat.},
  author={Natsuko Nozaki-Taguchi and Sandra R. Chaplan and Emiliano S. Higuera and R C Ajakwe and Tony L. Yaksh},
  volume={93 1},
The aims of this study were two-fold: first, to simplify the method for creating a recently described neuropathic pain model in the rat, and second, to evaluate the effects of a number of drugs with analgesic or antihyperalgesic properties, in this model. Continuous intravenous vincristine infusion (1-100 microg kg(-1) day (-1)) for 14 days resulted in a dose dependent tactile allodynia (as measured by von Frey filaments) by 7 days at doses between 30 - 100 microg kg(-1) day (-1), with a… CONTINUE READING