Vinca alkaloids and analogues as anti-cancer agents: Looking back, peering ahead.

  title={Vinca alkaloids and analogues as anti-cancer agents: Looking back, peering ahead.},
  author={Emanuela Di Martino and Giuseppe Casamassima and Sonia Castiglione and Edoardo Cellupica and Serena Pantalone and Francesca Papagni and Marta Rui and Angela Siciliano and Simona Collina},
  journal={Bioorganic \& medicinal chemistry letters},
  volume={28 17},

Anticancer potential of alkaloids: a key emphasis to colchicine, vinblastine, vincristine, vindesine, vinorelbine and vincamine

The comprehensive information provided in the review will be a valuable resource to develop an effective, affordable, and cost effective cancer management program using these alkaloids.

Status and Challenges of Plant-Anticancer Compounds in Cancer Treatment

Although more research is still necessary to develop more efficient and safe phytochemical drugs, more of these compounds might be used in future cancer therapies, as some strategies to face the limitations have been considered.

Phytochemicals in Cancer Treatment: From Preclinical Studies to Clinical Practice

The primary objective of this review is to describe what the authors know to date of the active compounds in the natural products, along with their pharmacologic action and molecular or specific targets.

Anti-cancer activities of Schedule E1 drugs used in ayurvedic formulations

Beyond the Paclitaxel and Vinca Alkaloids: Next Generation of Plant-Derived Microtubule-Targeting Agents with Potential Anticancer Activity

This work moves beyond the well-discussed paclitaxel and vinca alkaloids to present other promising plant-derived MTAs with potential for development as anticancer agents, and hopes that the review will provide guidance for further exploration and identification of more effective, novel MTAs derived from plant sources.

In vitro Antiproliferative Studies of Selected Medicinal Plants on Cancerous and Normal Cells

The study findings suggest exploitation of these plant extracts as potential candidates for development of drugs for the management of breast and prostate cancer.

Microtubule-targeting agents and their impact on cancer treatment.

Exploring the anticancer activities of novel bioactive compounds derived from endophytic fungi: mechanisms of action, current challenges and future perspectives.

This review highlights the anti-cancer activities of entophytic fungus against human papillary thyroid carcinoma, human pancreatic (PANC-1), ovarian (OVCAR-3), hepatic (HepG2), lung, human lymphoma (U937), human skin carcinoma (A431), breast (MCF-7), and Kaposi's sarcoma.




A phytochemical investigation of the plant Vinca rosea Linn has demonstrated that a number of alkaloidal substances can be obtained with antitumor activity, including vinblastine, vincristine, and vinrosidine, which are capable of prolonging and/or “curing” mice of the P-1534 leukemia.

PhytoNanotechnology: Enhancing Delivery of Plant Based Anti-cancer Drugs

This review presents a comprehensive review of formulation strategies of phytoconstituents in development of novel delivery systems like liposomes, functionalized nanoparticles (NPs), application of polymer conjugates along with their advantages over conventional drug delivery systems supported by enhanced biological activity in in vitro and in vivo anticancer assays.

Modifications in the "upper" velbenamine part of the Vinca alkaloids have major implications for tubulin interacting activities.

  • J. Fahy
  • Chemistry
    Current pharmaceutical design
  • 2001
This review will focus more specifically on derivatives which have been modified in the velbenamine part, with the aim of inducing different chemical and pharmacological properties.

Vinflunine: drug safety evaluation of this novel synthetic vinca alkaloid

Vinflunine is currently approved in Europe for the treatment of second-line TCCU and is currently being developed in other malignancies, where it has been shown to have predictable and manageable adverse effects, such as neutropenia, anemia, constipation and fatigue.

Microtubule destabilising agents: far more than just antimitotic anticancer drugs

The numerous cellular consequences of disrupting microtubules dynamics are highlighted, expanding the textbook knowledge of microtubule destabilising agents and providing novel opportunities for their use in cancer therapy.

Next Generation Antineoplastic Agents: A Review on Structurally Modified Vinblastine (VBL) Analogues.

The importance of vinblastine in cancer chemotherapy is highlighted as it is now possible to synthesize new molecules with activity in picomolar range and not only the periphery of the molecule, the core structure of this magical molecule can be modified to achieve next generation antineoplastic agents.

Vinflunine: clinical perspectives of an emerging anticancer agent

Noteworthy results from Phase II studies for treatment of non-small cell lung cancer, breast cancer and bladder cancer supported Phase III studies showed important results, and encouraging results of combination use of vinflunine and other biologic agents opened areas to investigate its synergistic or auxiliary role to existing therapies.

New insights into Vinca alkaloids resistance mechanism and circumvention in lung cancer.

The long story of camptothecin: From traditional medicine to drugs.

Natural products as antimitotic agents.

This review will consider the anti mitotic NP and their potential impact in the development of new therapeutic agents.