Vinca alkaloid skin toxicity: antidote and drug disposition studies in the mouse.

@article{Dorr1985VincaAS,
  title={Vinca alkaloid skin toxicity: antidote and drug disposition studies in the mouse.},
  author={Robert T. Dorr and David S. Alberts},
  journal={Journal of the National Cancer Institute},
  year={1985},
  volume={74 1},
  pages={113-20}
}
A murine (BALB/c) skin toxicity model was used to evaluate various possible antagonists to vinca alkaloid-induced skin ulceration. Reproducible dose-response relationships were developed for vinblastine (VBL) and vindesine (VDS). With vincristine (VCR) only about 70% of mice developed dose-dependent ulceration. On an equal weight basis, VCR proved to be significantly more toxic than either VBL or VDS (P less than .05 by Student's t-test). Effective local intradermal antidotes to VBL, VDS, and… CONTINUE READING
21 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 21 extracted citations

Similar Papers

Loading similar papers…