Vinca alkaloid-induced tubulin spiral formation correlates with cytotoxicity in the leukemic L1210 cell line.

@article{Lobert2000VincaAT,
  title={Vinca alkaloid-induced tubulin spiral formation correlates with cytotoxicity in the leukemic L1210 cell line.},
  author={Sharon Lobert and J. B. Fahy and Bridget T. Hill and Alain Duflos and Chantal Eti{\'e}vant and John J. Correia},
  journal={Biochemistry},
  year={2000},
  volume={39 39},
  pages={12053-62}
}
The ability of a class of C-20' modified vinca alkaloid congeners to induce tubulin spiral formation was investigated relative to their ability to inhibit microtubule assembly, their cytotoxicity against a leukemic cell line, L1210, and their measured and calculated partition coefficients. These studies were prompted by the observation that the energetics of vinca alkaloid-induced tubulin spiral polymers, or spiraling potential, is inversely related to their clinical dosage and are aimed at the… CONTINUE READING
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