Vimentin-positive astrocytes in canine distemper: a target for canine distemper virus especially in chronic demyelinating lesions?

@article{Seehusen2007VimentinpositiveAI,
  title={Vimentin-positive astrocytes in canine distemper: a target for canine distemper virus especially in chronic demyelinating lesions?},
  author={Frauke Seehusen and Enzo A. Orlando and Konstantin Wewetzer and Wolfgang Baumgaertner},
  journal={Acta Neuropathologica},
  year={2007},
  volume={114},
  pages={597-608}
}
In canine distemper demyelinating leukoencephalitis (DL), caused by canine distemper virus (CDV), astrocytes represent the main virus target. In these cells, glial fibrillary acidic protein (GFAP) is the main intermediate filament, whereas vimentin occurs early in the astrocytic lineage and is replaced gradually by GFAP. To further characterize the role of astrocytic infection in dogs with DL, an animal model for multiple sclerosis, formalin-fixed paraffin-embedded cerebella were investigated… CONTINUE READING