Vimentin is secreted by activated macrophages

@article{MorVaknin2003VimentinIS,
  title={Vimentin is secreted by activated macrophages},
  author={Nirit Mor-Vaknin and Antonello Punturieri and Kajal V Sitwala and David M. Markovitz},
  journal={Nature Cell Biology},
  year={2003},
  volume={5},
  pages={59-63}
}
Vimentin is a widely expressed intermediate filament protein thought to be involved mainly in structural processes, such as wound healing. We now demonstrate that activated human macrophages secrete vimentin into the extracellular space. The maturation of blood-derived monocytes into macrophages involves several signalling pathways. We show that secretion of vimentin, which is phosphorylated at serine and threonine residues, is enhanced by the phosphatase inhibitor okadaic acid and blocked by… CONTINUE READING

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