Vimentin intermediate filaments control actin stress fiber assembly through GEF-H1 and RhoA

@inproceedings{Jiu2017VimentinIF,
  title={Vimentin intermediate filaments control actin stress fiber assembly through GEF-H1 and RhoA},
  author={Yaming Jiu and Johan Per{\"a}nen and Niccole Schaible and Fang Cheng and John E. Eriksson and Ramaswamy Krishnan and Pekka Lappalainen},
  booktitle={Journal of cell science},
  year={2017}
}
The actin and intermediate filament cytoskeletons contribute to numerous cellular processes, including morphogenesis, cytokinesis and migration. These two cytoskeletal systems associate with each other, but the underlying mechanisms of this interaction are incompletely understood. Here, we show that inactivation of vimentin leads to increased actin stress fiber assembly and contractility, and consequent elevation of myosin light chain phosphorylation and stabilization of tropomyosin-4.2 (see… CONTINUE READING
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